Estadio Azteca showcases Monday Night Football between the San Francisco 49ers and the Arizona Cardinals. Kickoff in Mexico City is set for 8:15 p.m. ET. The 49ers are favored by 10 points in the latest 49ers vs. Cardinals odds from Caesars Sportsbook, while the over/under is 42.5. Before you make any 49ers vs. Cardinals picks or any other NFL predictions, you NEED to see which side SportsLine expert Micah Roberts is on. 

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He's also on an incredible 13-3 roll on his last 16 picks involving the 49ers! Anyone who has followed him is WAY UP.

The expert knows the 49ers are dominant on defense. San Francisco leads the NFL in total defense, giving up only 280.6 yards per game, and is No. 1 in first downs allowed and rushing yards allowed. The 49ers are in the top five in points allowed, yielding only 18.1 per game, and give up only 27.2 yards and 1.60 points per defensive possession. 

The expert also knows Arizona is averaging 23.0 points per game with 206 first downs this season. The Cardinals also project to have an edge in the turnover battle, committing only nine giveaways this season, and score a touchdown on 60% of trips inside the red zone.

Now, Roberts has locked in another confident against the spread pick for 49ers vs. Cardinals. We can tell you he's leaning Over the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins 49ers vs. Cardinals on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the 49ers vs. Cardinals spread to jump on, all from the expert who's an outstanding 13-3 on San Francisco picks!