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49ers vs. Bills line, odds, start time, picks, best bets for Sunday Night Football matchup from proven model

SportsLine's Projection Model, which is up well over $7,000 for $100 players on top-rated NFL picks since its inception, has locked in its San Francisco 49ers vs. Buffalo Bills picks on Sunday Night Football

The Buffalo Bills (9-2) have the San Francisco 49ers (5-6) coming to town for a primetime battle on Sunday Night Football. Buffalo has won six games in a row. Last time out, the Bills defeated the Kansas City Chiefs, 30-21, before going on bye. Meanwhile, the 49ers have dropped two straight games. In Week 12, the Green Bay Packers dominated San Francisco en route to a 38-10 victory. 49ers quarterback Brock Purdy is questionable with a shoulder injury and considerable lake effect snow is expected prior to kickoff.

Kickoff from Highmark Stadium in Buffalo is set for 8:20 p.m. ET. The Bills are 6.5-point favorites in the latest 49ers vs. Bills odds from the SportsLine Consensus, while the over/under for total points scored is 44.5. The Bills are -319 money line favorites (risk $319 to win $100), while the 49ers are +253 underdogs (risk $100 to win $253). Before making any 49ers vs. Bills picks, you NEED to see the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2024 NFL season on an incredible 22-8 hot streak on top-rated NFL picks this year. Longer term, it is on a 202-136 roll on top-rated NFL picks that dates back to the 2017 season and a 56-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

The model has simulated 49ers vs. Bills 10,000 times and the results are in. We can tell you the model is leaning Over on the point total, and it also says one side of the spread cashes in over 50% of simulations!

Who wins 49ers vs. Bills on Sunday Night Football, and which side of the spread cashes over 50% of the time? ... Join SportsLine right now to find out which side of the 49ers vs. Bills spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!

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SportsLine Staff
SportsLine Staff

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