Because of coronavirus restrictions in Santa Clara County, the San Francisco 49ers will host the Buffalo Bills on Monday Night Football in Glendale, Ariz. Kickoff is set for 8:15 p.m. ET. San Francisco is a two-point favorite in the latest 49ers vs. Bills odds from William Hill Sportsbook, while the Over-Under for total points scored is 47.5.

Before you make any 49ers vs. Bills picks, you NEED to see what SportsLine's resident 49ers expert, Tom Fornelli, has to say.

The CBS national writer went a wallet-fattening 31-21 last season on his NFL best bets. What's more, he has demonstrated a particularly sharp eye for the 49ers. In fact, he is 14-5 on picks involving San Francisco! Anyone who has followed him is WAY UP.

Now he's studied Bills vs. 49ers from every possible angle. We can tell you he's leaning Under the total, and he's also found a critical X-factor that has him jumping all over one side of the spread! You ABSOLUTELY need to see it before you lock in your own picks.

So who wins 49ers vs. Bills on Monday Night Football? And what critical X-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the Bills vs. 49ers spread you should be all over, all from the expert who's 14-5 on picks involving San Francisco!