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The 2026 NFL season continues on Sunday, and NFL bettors are looking for score predictions they can work off of to form spread, total, money-line and prop picks ahead of a massive Week 1 slate. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Some notable NFL spreads on the Week 1 NFL schedule include Bills vs. Texans (+1.5, 44.5), which has Houston as a home underdog, Cowboys vs. Giants (+3, 48) on Sunday night and Chiefs (-2.5, 43.5) on Monday.
Before you lock in any Week 1 NFL picks, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2026 NFL season on a 53-37 roll on top-rated NFL picks since 2024. Anyone following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 1 of the 2026 NFL season, and the results are in.
We can tell you SportsLine's model likes the Philadelphia Eagles (-5.5, 40.5) to beat the Washington Commanders, 27-18, at home. The Eagles have dominated this series recently, winning seven of the last 10 meetings against the Commanders. Washington has dropped eight of their last 10 games overall, while Philadelphia has won three of its last five games. In addition, the Commanders are 5-4-1 against the spread in their last 10 games against Philadelphia. The model projects Jalen Hurts of the Eagles will throw for 213 yards and 1.79 touchdowns, while Washington's defense racks up 2.64 sacks on average.
In addition, the model is calling for one specific underdog to pull off a SHOCKING upset! Nailing these results is key to making profitable Week 1 NFL picks. You ABSOLUTELY NEED to see who to pick before locking in any Week 1 NFL score predictions!
What are the projected scores for every Week 1 NFL game? And which underdog shocks the NFL? ... Join SportsLine now to get NFL Week 1 score predictions, all from the model on a dominant 53-37 roll!
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Written by Daniel Kohn
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