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Only one of the top four seeds has advanced to the 2026 U.S. Open men's semifinals. World No. 2 and top-seeded Alexander Zverev will take on unseeded Karen Khachanov in Friday's first match, followed by No. 11 Frances Tiafoe facing off against No. 8 seed Ben Shelton. Zverev is looking to win his second Grand Slam event this year, after winning the French Open in June. He placed second at Wimbledon in July. Khachanov, Tiafoe and Ben Shelton are all seeking a spot in a Grand Slam final for the first time. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:

The semis will start with Zverev vs. Khachanov at 3 p.m. ET from Arthur Ashe Stadium in Queens, N.Y. Zverev is the -487 favorite (risk $487 to win $100) to defeat Khachanov (+358) in the latest U.S. Open 2026 odds. The over/under for total games is 38.5. Meanwhile, Shelton is the -325 favorite over Tiafoe (+253), with that match's total games O/U at 39.5.

Before you make any U.S. Open picks or predictions, you must see the U.S. Open 2026 picks from tennis handicapper Jose Onorato.

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players.

Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis bets. He studies current form, players' tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach has helped Onorato go 168-106-8 (+107.12 units) since 2022. He correctly called Jannik Sinner in the 2025 Australian Open (+160), Carlos Alcaraz (+130) in the 2025 French Open and Sinner again at 2025 Wimbledon (+180). He also called Gauff (+700) in the 2025 French Open and Iga Swiatek (+1200) at 2025 Wimbledon. This year, he nailed Alexander Zverev (+700) in the 2026 French Open.

For the final grand slam tournament of the season, Onorato has broken down the latest odds for both 2026 U.S. Open men's semifinals and has identified his best bets.

We can tell you he is backing Under 38.5 games for Zverev vs. Khachanov.

Additionally, Onorato has thoroughly studied the men's semifinals and has identified multiple best bets! You ABSOLUTELY need to see what they are before locking in any 2026 U.S. Open men's picks of your own!

So where does all the value lie in the 2026 U.S. Open, and which men's semifinal picks should you target? ... Join SportsLine right now to see Jose Onorato's predictions and analysis for the 2026 U.S. Open men's semifinals, all from the tennis expert who is 168-106-8 since 2022!

Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.

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