2026 NFL Week 1 odds, score predictions: SportsLine AI reveals picks for every game
SportsLine AI reveals its NFL picks against the spread, over/under and money line for every NFL game in Week 1
loading...
loading...
The 2026 NFL schedule kicks off over a four out of six-day stretch when the New England Patriots battle the Seattle Seahawks on Wednesday, Sept. 9. The game will be a rematch from last February's Super Bowl LX game, which saw the Seahawks roll to a 29-13 win. The next night, Myles Garrett makes his Rams debut when Los Angeles takes on San Francisco at Melbourne, Australia. Thirteen games follow on Sunday, including a Sunday Night Football matchup between the Dallas Cowboys and New York Giants as John Harbaugh makes his New York debut as coach. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Week 1 ends with a Monday Night Football matchup between the Denver Broncos and Kansas City Chiefs. Sunday's largest spreads include Cardinals vs. Chargers (-9.5), Browns vs. Jaguars (-8.5) and Saints vs. Lions (-7). The smallest spreads in Week 1 include Bills vs. Texans (+1), Jets vs. Titans (-1.5) and Packers vs. Vikings (-1.5).
Before making any Week 1 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. It has nailed thousands of 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!
After analyzing every game in Week 1, the AI says the Ravens (-3.5) cover comfortably against the Colts. A healthy Lamar Jackson is back. Last season he played in 13 games and threw for 2,549 yards and 21 touchdowns with just seven interceptions.
SportsLine AI rates the Ravens as a A+ spread pick and also predicts a 29-16 win on average.
SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 1! In fact, the AI has generated several other HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 1 NFL bets.
Which NFL bets do you need to make NOW for Week 1? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2026 Week 1 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Daniel Kohn
View expert profile