2026 Hall of Fame Game odds, prediction: Panthers vs. Cardinals picks by expert on 50-37 roll

Mike LaFleur makes his coaching debut when his Arizona Cardinals battle the Carolina Panthers in the annual Hall of Fame Game in Canton, Ohio, on Thursday. Arizona is coming off a 3-14 season which saw it finish fourth in the NFC West. Carolina, meanwhile, finished 8-9 in 2025, good enough to win the NFC South title. Carolina has won just one of its last eight preseason games, while Arizona is 4-5 in the preseason during that same stretch.

Kickoff is set for 8 p.m. ET at Tom Benson Hall of Fame Stadium in Canton, Ohio. The Panthers are 1-point favorites in the latest Panthers vs. Cardinals odds, while the over-under for total points scored is 35.

Before making any Panthers vs. Cardinals picks, you NEED to see which side SportsLine NFL expert Larry Hartstein is on, considering his mastery of NFL picks.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He enters the 2026 NFL Hall of Fame Game on a 50-37-1 run on NFL spread picks, a 57.5% win rate. Anyone following has seen HUGE returns!

Now, Hartstein has locked in another confident against-the-spread pick for Panthers vs. Cardinals. 

We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Panthers vs. Cardinals in the NFL Hall of Fame Game, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Panthers vs. Cardinals spread to back, all from the expert who went 50-37-1 on his NFL picks in 2025!

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