2025 Orange Bowl odds, spread, line, time: Notre Dame vs. Penn State predictions, CFP picks from expert on 16-2 run

The final four of the 2025 College Football Playoff has arrived with Thursday's Orange Bowl setting half of the CFP Title Game. No. 6 Penn State takes on No. 7 Notre Dame after both cruised to double-digit victories in the opening playoff rounds. Penn State boasts a 13-2 record behind a dominant defense that ranks among the top five, nationally, in both points per game and yards per game allowed. Notre Dame comes in at 13-1 with top-three rankings in FBS in both scoring offense and scoring defense. The all-time series is tied 9-9-1, with Penn State winning the last meeting in 2007.

Kickoff is set for 7:30 p.m. ET from Hard Rock Stadium in Miami Gardens, Fla. The Fighting Irish are 1-point favorites in the latest Notre Dame vs. Penn State odds via SportsLine consensus, while the over/under for total points scored is 45.5. Both teams are listed at -110 on the money line (risk $110 to $100) (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Penn State vs. Notre Dame picks or any other college football predictions, you NEED to see which side proven SportsLine college football expert Adam Silverstein is on. 

CBS Sports' managing editor, Silverstein is on a 16-2 (+1375) run on his last 18 selections in games involving the Nittany Lions. Anyone who has followed him could be way up.

Now, Silverstein has analyzed Notre Dame vs. Penn State from every angle and just locked in his 2025 Orange Bowl picks and CFP predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Penn State vs. Notre Dame in their Orange Bowl matchup, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 16-2, returning $1,375 for $100 bettors over his last 18 picks in Penn State games, and find out!