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Rams vs. 49ers lines, picks: Proven NFL model reveals picks for Week 18 clash

SportsLine's projection model simulated the Week 18 game between Los Angeles and San Francisco 10,000 times and revealed its results
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The San Francisco 49ers attempt to clinch the final wild-card berth in the conference when they visit on the playoff-bound Los Angeles Rams in the regular-season finale for the NFC West rivals on Sunday. San Francisco (9-7) needs a victory or a tie in the divisional showdown, or a loss or tie by New Orleans in its meeting with Atlanta to punch its ticket to the postseason. Los Angeles (12-4) will claim the NFC West title with a win or tie against the 49ers, or a loss or tie by Arizona in its battle with Seattle.

Kickoff from SoFi Stadium is set for 4:25 p.m. ET. Los Angeles is a 4.5-point favorite in the latest Rams vs. 49ers odds from Caesars Sportsbook, while the over-under for total points scored is 44.5.

Before making any 49ers vs. Rams picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up over $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 18 of the 2021 season on an incredible 135-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows San Francisco could have rookie Trey Lance under center as it attempts to secure just its second postseason berth in eight years. Starting in place of the injured Jimmy Garoppolo (thumb) last week, the 21-year-old Lance completed 16-of-23 pass attempts for 249 yards and a pair of touchdowns as he helped guide the 49ers to a 23-7 triumph over Houston. San Francisco rolled to a 31-10 home victory over the Rams in Week 10 to extend its winning streak in the all-time series to five games.

The model also knows Los Angeles is seeking its third NFC West title in five seasons as it attempts to end the regular season with a six-game winning streak. The Rams trailed throughout their game at Baltimore last week before Matthew Stafford threw a seven-yard touchdown pass to Odell Beckham Jr. with less than a minute remaining to give them a 20-19 victory. Cooper Kupp, who leads the NFL with 1,829 receiving yards and 15 TD catches, is 11 receptions away from tying the league's single-season record of 149 set in 2019 by New Orleans' Michael Thomas.

Now, the model has set its sights on Rams vs. 49ers. We can tell you it is leaning Over, and it also says one side of the spread cashes in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Rams vs. 49ers on Sunday? And which side of the spread hits over 50 percent of the time? ... Join SportsLine right now to find out which side of the 49ers vs. Rams spread you need to jump on, all from the model on a 135-96 roll on NFL picks

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SportsLine Staff

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