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NFL odds, lines, spreads: 2021 Week 1 picks, predictions from proven model

The SportsLine Projection Model, which is up almost $7,900 for $100 players on top-rated NFL picks since its inception, has revealed its Week 1 NFL picks
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Week 1 of the 2021 NFL season features multiple mouthwatering matchups, including Cowboys vs. Buccaneers, Steelers vs. Bills, Browns vs. Chiefs and Packers vs. Saints. The reigning Super Bowl champions are eight-point favorites against the Cowboys in the latest Week 1 NFL odds from Caesars Sportsbook. Meanwhile, the Bills are -6.5 against the Steelers, the Chiefs are -6 against the Browns and the Packers are -4 against the Saints. 

Before making any NFL picks for Week 1, be sure to see what the SportsLine Projection Model has to say. 

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has evaluated the latest odds from Caesars, simulated every snap for Week 1 of the 2021 NFL season, and the results are in. 

We can tell you one of the model's strongest Week 1 NFL picks is that the 49ers (-8.5) cover against the Lions in nearly 60 percent of simulations! Another one of its Week 1 NFL predictions: The Panthers (-4) cover the spread at home against the Jets well over 50 percent of the time. The model also says the Over (45.5) has all the value in that matchup.  

The model has also made the call on who wins and covers every other NFL game this week and has identified a Super Bowl contender that goes down HARD! You ABSOLUTELY need to see its NFL picks for every single game before locking in your own.

So which NFL teams should you back this week? And which Super Bowl contender goes down? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $7,900 in profit on top-rated picks since its inception!

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SportsLine Staff