The No. 11 seed Michigan Wolverines (19-14) and the No. 2 seed Villanova Wildcats (28-7) clash in the Sweet 16 round of the 2022 NCAA Tournament on Friday at 7:29 p.m. ET. Villanova is favored by five points at Caesars Sportsbook, while the Over-Under is set at 135.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Michigan vs. Villanova picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Villanova grad student guard Collin Gillespie is leading the way with 16 points, 3.8 rebounds and 3.4 assists per game. Gillespie has a well-rounded offensive game, logging at least 17 points in four of his last 10 matchups. The Pennsylvania native is also shooting 41 percent from downtown. In the win over Ohio State in the second round, Gillespie had 20 points and four assists. 

The model also knows Michigan sophomore center Hunter Dickinson is a very skilled big man. He leads the team in points (18.7), rebounds (8.4) and field-goal percentage (.571). Dickinson can score inside and out. He uses his size and length in the paint but can step back and knock down a jumper with ease. In the upset win over Tennessee, the Virginia native had 27 points, 11 rebounds and four assists. 

Now, it has set its sights on Michigan vs. Villanova. We can tell you the model is leaning Over the total, and it also says one side of the spread hits more than 50 percent of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Michigan vs. Villanova? And which side of the spread hits more than 50 percent of the time? ... Join SportsLine right now to find out which side of Michigan vs. Villanova spread you should be all over Thursday, all from the model on a roll on college basketball picks!