Teams are starting to separate. This is a weekend with some marquee matchups and I could see several of them being more lopsided than the lines suggest.

There are some teams that are starting to really flex their muscles with running the football – still essential at this time of year – and they're up against defenses that I just don't think can hold up against them. And, yeah, you'd better be including the Bills among those top rushing teams, who don't have to face a potential playoff team for the first time in a long time and will come away from this weekend only bolstering their playoff credentials.

Before you make your Week 16 picks, you'll want to see what NFL expert Jason La Canfora has to say. La Canfora has broken the games down and found a number of best bets, including wagers on the Ravens at 49ers game. He also has a selection of picks for Thursday Night Football. You NEED to see his analysis before locking in any NFL picks of your own. 

• More Week 16 picks: Model | Parlay | Pick 'Em | Survivor

What's the expert's play for Ravens-49ers? And what are the rest of his NFL Week 16 picks? Join SportsLine right now to see all of Jason La Canfora's best bets!