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College football odds, lines, spreads: Picks, predictions, betting advice for Week 12, 2021 from proven model

The SportsLine Projection Model, which has generated almost $3,500 for $100 college football bettors over the past five-plus years, has revealed its college football picks for Week 12
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The Week 12 college football schedule starts off with five MACtion games early in the week, and then action on Thursday, Friday and Saturday. Matchups of note that could impact the CFB Playoff chase include No. 4 Ohio State vs. No. 7 Michigan State (+19), SMU vs. No. 5 Cincinnati (-12), No. 3 Oregon vs. No. 23 Utah (-3) and the 3:30 p.m. ET SEC on CBS matchup between No. 21 Arkansas and No. 2 Alabama.

Before making any college football picks for those games or others in Week 12, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also entered Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds from Caesars Sportsbook (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 12 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 12: No. 18 Pittsburgh (-14.5) covers at home against a struggling Virginia squad at 3:30 p.m. ET on Saturday. The Panthers cover in well over 50 percent of simulations as Heisman candidate Kenny Pickett throws for almost 350 yards in the simulations. The under 66.5, meanwhile, hits almost 60 percent of the time. 

Another prediction: No. 6 Michigan (-15) covers over 60 percent of the time at Maryland in a 3:30 p.m. ET kickoff on Saturday. The under (57.5) is a value play in that Big Ten matchup as well since it hits over 60 percent of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it is predicting an upset that will impact the College Football Rankings in a BIG way. You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which underdog do you need to jump on NOW? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $3,500 in profit on top-rated ATS picks over the past five-plus seasons!

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SportsLine Staff