The Brigham Young Cougars will take on the USC Trojans at 5 p.m. ET Wednesday at Imperial Arena. It is a quarterfinals matchup of the 2022 Battle 4 Atlantis. USC is 2-1 while the Cougars are 3-1. BYU and USC are both first in their respective divisions (the West Coast and the Pac-12).

The Cougars are favored by 2 points in the latest Brigham Young vs. USC odds from Caesars Sportsbook, and the over/under is set at 140.5. Before you make any USC vs. Brigham Young picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,400 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, it has simulated Brigham Young vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Brigham Young vs. USC? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!