The Colorado Buffaloes and the Boise State Broncos are set to battle it out in a First Four matchup in the 2024 NCAA Tournament on Wednesday. The winner will be the No. 10 seed in the South Region and will face the No. 7 seed Florida Gators in the first round on Friday. The Buffs finished the regular season with a 24-10 overall record and reached the Pac-12 Tournament championship game where they lost to Oregon. The Broncos went 22-10, finishing third in the Mountain West during the regular season before losing to New Mexico in the MWC Tournament quarterfinals. 

Tipoff is set for 9:10 p.m. ET from Dayton, Ohio. The Buffs are 3.5-point favorites in the latest Colorado vs. Boise State odds via SportsLine consensus, while the over/under is 143.5 points (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Boise State vs. Colorado picks, you need to check out the college basketball predictions and betting advice from the SportsLine expert Jimmie Kaylor.

Kaylor is a betting and DFS expert for SportsLine, who has covered college sports and the NFL for close to a decade as a member of the Pro Football Writers of America. His background as a former high level athlete -- he was a Division-I All-American and professional athlete -- gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college basketball landscape and has been cashing in big for SportsLine members for the last two years. 

Kaylor enters the 2024 NCAA Tournament on a 19-9 run on his college basketball picks for SportsLine. He is up 10.1 units, returning a profit of $1,010 for $100 bettors. In Tuesday's First Four matchup between Virginia and Colorado State, Kaylor went 3-1, returning a profit of $190 for $100 bettors. Anyone who has followed his picks this season is way up!

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Boise State in their First Four matchup of the 2024 NCAA Tournament. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own. 

Who wins Boise State vs. Colorado in the First Four, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the proven expert who has been cashing BIG for SportsLine members for the last two years!