The Arizona Cardinals will look to move closer to earning a playoff spot when they take on the visiting San Francisco 49ers on Saturday. Kickoff from State Farm Stadium in Glendale, Ariz., is set for 4:30 p.m. ET. Arizona is favored by six points at William Hill Sportsbook, while the Over-Under is 48.5. Before making any 49ers vs. Cardinals picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 22-11 on top-rated NFL picks this season, returning over $800. The model also enters Week 16 on an incredible 118-76 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is WAY UP.    

Now, it has set its sights on 49ers vs. Cardinals. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins 49ers vs. Cardinals on Saturday? And which side of the spread cashes in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the 49ers vs. Cardinals spread you should be all over Saturday, all from the model on a 118-76 roll on NFL picks!