Notre Dame has a really good offensive line, maybe the best OL in the nation, and a strong run game with a stable of talented backs. They should have success against Louisville's defense that has been a bit vulnerable in that regard. Where Louisville has a puncher's chance is with their offense. With QB Malik Cunningham, WR Tutu Atwell and RB Javien Hawkins, that's more than enough explosive athletes than Notre Dame will be able to contain defensively.

Notre Dame is undefeated this season but has gotten there by facing the lackluster offenses of Duke, USF and Florida State. This Cardinals offense is far and away the most explosive unit it will have faced, and I don't have enough confidence in the Irish offense to think it can cover a spread this large against an offense like Louisville's.