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World Series Astros vs. Phillies odds, picks: Advanced computer MLB model releases selections for Game 4 matchup

SportsLine's projection model generated selections for Wednesday's Game 4 matchup between the Houston Astros and the Philadelphia Phillies
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The Philadelphia Phillies welcome the Houston Astros to Citizens Bank Park for Game 4 of the 2022 World Series at 8:03 p.m. ET on Wednesday. . Caesars Sportsbook lists Philadelphia as the -115 (risk $115 to win $100) favorite on the money line in the latest Astros vs. Phillies odds. Houston is -105 and the over/under for total runs is set at 7.5. (see up-to-date odds for every game this week on our MLB odds page). 

Before making any Astros vs. Phillies picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen HUGE returns.

The model knows the Astros have the best bullpen in baseball, leading MLB in ERA and strikeout rate during the regular season and posting elite metrics in the playoffs. Houston's offense is also tremendous, having slugged 214 regular season home runs. The Astros finished the 162-game marathon with top-three marks in runs scored, walks, strikeout avoidance, OPS, and total bases. The model also knows the Phillies have a tremendous starting pitcher on the bump. Aaron Nola led the National League by issuing only 1.3 walks per nine innings, and he generated 10.3 strikeouts per nine innings. He also posted a 3.25 ERA in 2025 innings, with elite underlying metrics.

Now, it has set its sights on Astros vs. Phillies. We can tell you the model is leaning Over the total, and it also says one team has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks.

Who wins Astros vs. Phillies? And which team has ALL the value on the money line? ... Join SportsLine right now to find out which side of the Astros vs. Phillies matchup you should be all over Wednesday, all from the model on a roll on MLB picks!

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SportsLine Staff

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