A Big East battle is on tap between the No. 19 Villanova Wildcats and the Creighton Bluejays at 8:30 p.m. ET on Wednesday at Finneran Pavilion. The Wildcats are 9-4 overall and 4-0 at home, while Creighton is 10-3 overall and 2-0 on the road. The Wildcats are favored by 10.5 points in the latest Villanova vs. Creighton odds from Caesars Sportsbook, and the over-under is set at 129.5. Before you make any Creighton vs. Villanova picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Villanova vs. Creighton 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Villanova vs. Creighton? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!