A spot in the 2022 Big South Tournament semifinals will be on the line when the USC Upstate Spartans face the Charleston Southern Buccaneers in a quarterfinal game on Friday at Bojangles Coliseum in Charlotte, N.C. Seeded No. 4 in the tournament, USC Upstate (13-15) received a first-round bye. Meanwhile Charleston Southern (6-24), the No. 12 seed, is coming off a 79-78 upset over UNC Asheville in the first round of the tournament on Wednesday. 

Tip-off is set for 2 p.m. ET. The Spartans are favored by 5.5 points in the latest USC Upstate vs. Charleston Southern odds from Caesars Sportsbook, while the Over/Under for total points scored is 143. (See up-to-date odds for every game this week on our college basketball odds page.)

Before making any Charleston Southern vs. USC Upstate picks, be sure to check out what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every Div. I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of more than $1,700 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that USC Upstate has one of the best scorers in the Big South in Bryson Mozone. The 6-foot-6 senior from North Augusta, S.C., ranks sixth in the conference in points per game (15.2). He is averaging even more during conference play (16.3). For his efforts this season he was named to the all-Big South second team.

The model also knows that Charleston Southern has one of the conference's most dangerous shooters in Tahlik Chavez. The 6-foot-2 junior from Arlington, Texas, leads the Big South in 3-pointers per game (2.87). He also ranks fourth in the conference in 3-point field goal percentage (36.8).

Now, the model has set its sights on the Big South quarterfinals and USC Upstate vs. Charleston Southern. We can tell you it is leaning Under the total, predicting a combined 142 points, and it also says one side of the spread covers in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins USC Upstate vs. Charleston Southern? And which side of the spread covers in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Charleston Southern vs. USC Upstate spread you should be all over Friday, all from the model on a roll on college basketball picks!