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Syracuse vs. Wake Forest odds, line, spread: Proven model reveals college football picks, predictions for Week 6, 2021

The SportsLine Projection Model simulated Syracuse vs. Wake Forest 10,000 times and revealed its college football picks
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An ACC battle is on tap between the Syracuse Orange and the No. 19 Wake Forest Demon Deacons at 3:30 p.m. ET on Saturday at Carrier Dome. Syracuse is 3-2 overall and 2-1 at home, while Wake Forest is 5-0 overall and 1-0 on the road. 

The Demon Deacons are favored by six points in the latest Syracuse vs. Wake Forest odds from Caesars Sportsbook, and the over-under is set at 58.5. Before you make any Wake Forest vs. Syracuse picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Syracuse vs. Wake Forest 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Syracuse vs. Wake Forest? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!

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SportsLine Staff