Russell Wilson and the Denver Broncos are set to host Jimmy Garoppolo and the San Francisco 49ers on Sunday Night Football. The game will be played at Empower Field at Mile High in Denber and kickoff is scheduled for 8:20 p.m. ET. The 49ers have won six of their last nine meetings against the Broncos, but they're just 1-4 in their last five games in Denver. 

There are plenty of ways to get in on the action for this primetime showdown. Same-game parlays are becoming increasingly popular among sports bettors because they combine picks like spread, total, money line and props for the chance at a huge payout.

Before locking in any same-game parlays for 49ers vs. Broncos, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best same-game parlay picks that he shares with SportsLine users. And on Monday, he nailed his Titans-Bills same-game parlay, returning +100!

Now, McClure has turned his attention to Broncos vs. 49ers on Sunday Night Football and locked in his top single-game parlay picks. 

We can tell you part of McClure's same-game parlay features 49ers tight end George Kittle recording over 25 receiving yards. Kittle is expected to make his season debut after missing the first two games due to a groin injury. San Francisco's star tight end averaged 12.8 yards per reception during the regular season in 2021 and he has a solid rapport with Garoppolo, so he could be targeted early and often on Sunday night. 

McClure is also targeting TWO other picks in his same-game parlay and the final payout comes out to plus-money. You ABSOLUTELY need to see who it is before locking in any parlays.

What is top same-game parlay combination for 49ers vs. Broncos? And which overlooked player props do you need to be all over? ... Join SportsLine now to see DFS pro Mike McClure's top same-game parlay picks, all for a shot at a plus-money return!