Week 2 of the 2022 NFL schedule concludes with a Monday Night Football doubleheader. Josh Allen and the Buffalo Bills will try to prove their Week 1 demolition of the reigning Super Bowl champions was no fluke. The Bills, who routed the Rams in the NFL Kickoff Game, will host the Tennessee Titans in the early Monday Night Football game (7:15 p.m. ET). The Titans were edged 21-20 by the New York Giants in their opener.

The second game features a pair of 1-0 teams, with the Minnesota Vikings visiting the Philadelphia Eagles (8:30 p.m. ET). Minnesota was impressive in knocking off the Green Bay Packers in Week 1, while Philadelphia posted a 38-35 victory against the Detroit Lions.

The season's opening week typically leads to overreactions, and there were plenty of unexpected results this time around. So before you make your Week 2 NFL picks and Monday Night Football parlays, you NEED TO see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model entered Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated every snap of both Monday Night Football games in Week 2 of the 2022 NFL season and revealed its best parlay picks. The four-leg parlay could lead to a payout of more than 12-1!

One part of the four-leg parlay the model is behind: Over 47.5 points (-110) in the Bills vs. Titans matchup. Projections show both Allen and Tennessee star running back Derrick Henry shining in the primetime spotlight, and the Over hits almost 60 percent of the time. You can have confidence in locking that in as part of your Monday Night Football parlay.

The model also is highly recommending three other picks for an NFL parlay involving Monday's games, including an underdog that wins in almost half of simulations! You ABSOLUTELY need to see who to pick before locking in any NFL parlays.

So which teams win in Week 2's Monday Night Football doubleheader? And which underdog is a MUST-BACK for a payout of more than 12-1? ... Join SportsLine here to see what picks to include in your four-leg parlay, all from the model that has returned over $7,500 on its top-rated picks!