An American Athletic battle is on tap between the Memphis Tigers and the SMU Mustangs at noon ET on Saturday at Liberty Bowl Memorial. Memphis is 4-4 overall and 3-1 at home, while SMU is 7-1 overall and 3-1 on the road. The Mustangs are ranked second in the American Athletic's West Division; the Tigers are ranked fifth. 

The Mustangs are favored by 4.5 points in the latest Memphis vs. SMU odds from Caesars Sportsbook, and the over-under is set at 70.5. Before you make any SMU vs. Memphis picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Memphis vs. SMU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Memphis vs. SMU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!