The Syracuse Orange attempt to end their five-game losing streak when they visit the Louisville Cardinals on Friday in an Atlantic Coast Conference matchup. Kickoff from Cardinal Stadium is set for 7 p.m. ET. The Cardinals are 19.5-point favorites in the latest Louisville vs. Syracuse odds from William Hill Sportsbook, while the over-under for total points scored is 54.5 (see the latest college football lines for all of this week's games on our college football odds page).

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