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Louisville vs. Pittsburgh odds, line, spread: Proven model reveals college basketball picks, predictions for Jan 5, 2022

The SportsLine projection model has simulated Wednesday's matchup between Louisville and Pittsburgh 10,000 times and revealed its college basketball picks.
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After a bumpy start to the season, Pittsburgh has begun turning things around over its last three games, and will try to keep things going in an ACC matchup at Louisville on Wednesday at 7 p.m. ET. The Cardinals have won the last four meetings against the Panthers, and Pitt is just 6-19 all-time in rivalry between the two. Louisville has opened ACC play with three consecutive wins, after finishing seventh in the conference last season.

The Cardinals are favored by 12.5 points in the latest Louisville vs. Pittsburgh odds from Caesars Sportsbook, and the over-under is set at 130. Before you make any Pittsburgh vs. Louisville picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Louisville vs. Pittsburgh 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in just over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Louisville vs. Pittsburgh? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks ... If you're already a member, see the picks below!

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SportsLine Staff