The No. 20 Florida State Seminoles will take on the visiting Indiana Hoosiers in a 2020 ACC/Big Ten Challenge on Wednesday. Tip-off from Tucker Center in Tallahassee, Fla., is set for 7:15 p.m. ET. Florida State is favored by 3.5-points at William Hill Sportsbook, while the Over-Under is set at 140 (see up-to-date odds for every game this week on our college basketball predictions page). Before making any Indiana vs. Florida State picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,700 for $100 players on its top-rated college basketball picks against the spread. It's also off to a fast start in the 2020-21 season, going 5-1 on all its top-rated picks and returning over $400. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Indiana vs. Florida State. We can tell you the model is leaning under the total, and it also says one side of the spread hits in well over 70 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Indiana vs. Florida State? And which side of the spread hits in well over 70 percent of simulations? ... Join SportsLine right now to find out which side of the Indiana vs. Florida State spread you should be all over Wednesday, all from the model on a roll on college basketball picks!