A National League matchup has the San Francisco Giants (65-72) and the Chicago Cubs (57-80) squaring off on Friday afternoon, with the first pitch set for 4:05 p.m. ET. The Giants are listed as the -160 favorites (risk $160 to win $100) on the money line in the latest Giants vs. Cubs odds from Caesars Sportsbook, while the over/under for total runs scored is 7.5 (see up-to-date odds for every game this week on our MLB odds page).

Before making any Giants vs. Cubs picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 311-271 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows Giants left fielder Joc Pederson is a smooth athlete who owns a quality swing. Pederson has the plate coverage and bat speed to pull the ball hard. The two-time All-Star is batting .265 with 22 home runs and 62 RBI. In his last outing, he belted a solo home run.

The model also knows Cubs right fielder Seiya Suzuki brings a calm approach to the dish. He owns the power to drive the baseball out of the park with his explosive swing. Suzuki also has a strong arm and can deliver a rocket from the outfield. His batting average is .264 with 12 dingers and 44 RBI. On Sept. 8, he was 2-for-4 with a double and a solo home run. 

Now, the model has set its sights on Giants vs. Cubs. We can tell you the model is leaning Under the total, and it also says one side of the money line has hits in 60% of simulations. You ABSOLUTELY need to see it before locking in any MLB picks.

So who wins Giants vs. Cubs? And which side of the money line hits in 60% of simulations? Join SportsLine here to find out, all from the model that has crushed its top-rated MLB money-line picks!