Week 5 brought more injuries to the RB position, as well as some shifting backfield depth chart situations that are worth being aware of. Dalvin Cook and Chris Carson were ruled out before their games started, while Saquon Barkley and Clyde Edwards-Helaire both suffered in-game injuries that are likely to keep them sidelined for multiple weeks. Week 5's injuries opened up short-term starting opportunities for several running backs, and it brought us our first look at Chicago's backfield without David Montgomery leading the way. Damien Williams enjoyed a productive Fantasy day, but rookie Khalil Herbert mixed in quite a bit on early downs. Read about that and other developing situations in the Week 5 RB Usage Report.

One of the biggest rankings climbers in Week 5 was Miami RB Myles Gaskin. The Dolphins had appeared to be moving away from Gaskin in favor of Malcolm Brown, but that wasn't the case in Week 5. Gaskin looked like the Fantasy stud that we saw during the 2020 season, playing two-thirds of the snaps and drawing targets at a high rate. He joins Josh Jacobs, Cordarelle Patterson, and Zack Moss as the running backs who saw their rest of season rank change the most from Week 5 to Week 6.

After evaluating the data and sharing What We Learned in Week 5, I'm ready to lay out my rest-of-season rankings at the running back position heading into Week 6. Here's where I'm ranking each RB going forward, given the data we have through three weeks.

Tiered rest of season RB rankings

Tier 1

1. Christian McCaffrey

Tier 2

2. Dalvin Cook
3. Aaron Jones
4. Austin Ekeler 
5. Derrick Henry
6. Alvin Kamara
7. Ezekiel Elliott

Tier 3

8. D'Andre Swift
9. Najee Harris 
10. Nick Chubb
11. Joe Mixon

Which RBs are on the rise after five weeks? And which every-week starter has us concerned with his role thus far? ... Join SportsLine here to see Jacob Gibbs' rest of season Fantasy Football Rankings, all from one of the nation's most accurate experts as graded by FantasyPros!