The Chicago Cubs go for a three-game sweep when they meet the Pittsburgh Pirates on Wednesday afternoon at PNC Park in Pittsburgh. First pitch is at 12:35 p.m. ET. William Hill Sportsbook lists Chicago as the -135 favorite (risk $135 to win $100) in the latest Cubs vs. Pirates odds. The Over-Under for total runs scored is 7.5. (See the latest lines for every game on our MLB odds page in this matchup.)

Before making any Pirates vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen huge rewards!

Now, it has set its sights on Cubs vs. Pirates. We can tell you it's leaning Over the total, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

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