Trevor Lawrence returns from a two-game absence due to COVID-19 when the fourth-ranked Clemson Tigers host the Pittsburgh Panthers on Saturday in an Atlantic Coast Conference matchup. Kickoff from Memorial Stadium in Clemson, SC is set for 3:30 p.m. ET. The Tigers are 24-point favorites in the latest Clemson vs. Pittsburgh odds from William Hill Sportsbook, while the over-under for total points scored is 58 (see the latest college football lines for all of this week's games on our college football odds page).
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