The No. 6 LSU Tigers begin the defense of their national championship when they host the Mississippi State Bulldogs on Saturday in an SEC on CBS matchup. Kickoff is set for 3:30 p.m. ET from Tiger Stadium in Baton Rouge. The Tigers are 16.5-point favorites in the latest LSU vs. Mississippi State odds from William Hill, while the over-under for total points scored is 57. Before making any LSU vs. Mississippi State picks, be sure to check out the FBS college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,800 for $100 players on its top-rated college football picks against the spread. It is a sizzling 13-1 on top-rated picks through three weeks of the 2020 college football season, returning over $900 in profit already. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on LSU vs. Mississippi State. We can tell you it's leaning Under, and it's also generated an against-the-spread pick that cashes in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any FBS college football picks of your own.

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