The No. 17 SMU Mustangs visit the Tulane Green Wave for an American Athletic Conference showdown on Friday night. The Mustangs are 6.5-point favorites in the latest SMU vs. Tulane odds from William Hill, while the over-under for total points scored is 66. Before making any SMU vs. Tulane picks, be sure to check out the FBS college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,200 for $100 players on its top-rated college football picks against the spread. It is a sizzling 23-6 on top-rated picks through six weeks of the 2020 college football season, returning almost $1,300 in profit already. Anyone who has followed it has seen HUGE returns.

Now, it has locked in on SMU vs. Tulane. We can tell you it's leaning Over, and it also says one side of the spread hits nearly 60 percent of the time. You ABSOLUTELY need to see it before locking in any FBS college football picks of your own.

Who wins SMU vs. Tulane? And which side of the spread hits nearly 60 percent of the time? ... Join SportsLine right now to see which side of the SMU vs. Tulane spread to back on Friday, all from the advanced model on a 23-6 run on top-rated picks to start the season!