The Dallas Cowboys will find out what life without quarterback Dak Prescott (ankle) is like when they take on the Arizona Cardinals on Monday Night Football. Prescott is expected to miss the rest of the season after going down against the New York Giants last week.

Kickoff from AT&T Stadium in Arlington, Texas, is set for 8:15 p.m. ET. Dallas is a one-point favorite in the latest Cardinals vs. Cowboys odds from William Hill, while the over-under is 55. Before you make any Cardinals vs. Cowboys picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception five-plus years ago. It's off to a strong 10-5 roll on top-rated NFL picks this season. The model enters Week 6 on an incredible 106-70 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is WAY UP.    

Now, it has set its sights on Cardinals vs. Cowboys. We can tell you it's leaning Under, and it also says one side of the spread cashes in over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks of your own.

So who wins Cardinals vs. Cowboys on Monday Night Football? And which side of the spread hits more than 60 percent of the time? ... Join SportsLine right now to find out which side of the Cardinals vs. Cowboys spread you should be all over, all from the advanced model that has returned over $7,500 on top-rated NFL picks!