The No. 16 Virginia Cavaliers will take on the William & Mary Tribe at 2 p.m. ET Tuesday at John Paul Jones Arena. The Cavaliers are 3-1 overall and 2-0 at home, while William & Mary is 2-2 overall and 2-1 on the road. The Cavaliers are favored by 22.5 points in the latest Virginia vs. William & Mary odds from William Hill, and the Over-Under is set at 122.5. Before you make any William & Mary vs. Virginia picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,600 for $100 players on its top-rated college basketball picks against the spread. It's off to a profitable start in the 2020-21 season, going 12-9 on all its top-rated picks and returning almost $300. Anyone who has followed it has seen huge returns.

Now, it has simulated Virginia vs. William & Mary 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Virginia vs. William & Mary? And which side of the spread is hitting in almost 70 percent of simulations? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!