A Big Ten battle is on tap Wednesday between the Purdue Boilermakers and the No. 20 Ohio State Buckeyes at 7 p.m. ET at Mackey Arena. Purdue is 4-2 overall and 3-0 at home, while the Buckeyes are 5-0 overall and 1-0 on the road. The Boilermakers are favored by 5 points in the latest Purdue vs. Ohio State odds from William Hill Sportsbook, and the Over-Under is set at 133.5. Before you make any Ohio State vs. Purdue picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,600 for $100 players on its top-rated college basketball picks against the spread. It's also off to a fast start in the 2020-21 season, going 8-4 on all its top-rated picks and returning well over $300. Anyone who has followed it has seen huge returns.

Now, it has simulated Purdue vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Purdue vs. Ohio State? And which side of the spread is hitting in well over 60 percent of simulations? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!