Get ready for an American Athletic battle as the SMU Mustangs and the East Carolina Pirates will face off at noon ET on Saturday at Gerald J. Ford Stadium. The Mustangs are favored by 21.5 points in the latest SMU vs. East Carolina odds, while the Over-Under is set at 70. Before you make any East Carolina vs. SMU picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen huge returns. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,000 for $100 players on its top-rated college football picks against the spread. The model enters Week 11 of the 2019 season on a strong run, going 105-69 on all its top-rated college football picks this season. Anybody who has been following it is way up.

Now, it has simulated SMU vs. East Carolina 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins SMU vs. East Carolina? And which side of the spread is hitting in over 60 percent of simulations? ... Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!