The 2023 NFL Thanksgiving schedule closes with a matchup between the San Francisco 49ers and Seattle Seahawks. Kickoff in Seattle is set for 8:20 p.m. ET. For this game, SportsLine consensus lists the 49ers as seven-point favorites, while the over/under is 44. Seahawks running back Kenneth Walker is doubtful with an oblique injury. Before you make any 49ers vs. Seahawks picks or any other NFL predictions, you NEED to see which side Josh Nagel is on, given his mastery of picks involving Seattle. 

Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests. He prides himself on consistency and insightful analysis.

Moreover, Nagel has a read on the pulse of the Seahawks. In fact, he is a blistering 24-10 (+1300) on his last 34 picks in games involving Seattle! Anyone who has followed him is WAY UP!

The expert knows the 49ers lead the NFL in allowing only 15.7 points per game. San Francisco is also in the top five in allowing 302.8 total yards per game, with opponents averaging only 4.9 yards per play. The 49ers are in the top three in run defense and lead the league in turnover creation rate (18.3%) with 19 takeaways and 14 interceptions. 

The expert also knows Seattle is on a four-game winning streak at Lumen Field, scoring at least 20 points in each victory. The Seahawks are generating more than 27 points per game in those four home victories and put up 489 total yards and 6.6 yards per play in its last home game against Washington. For the season, the Seahawks are averaging 5.8 yards per play in home games.

Now, Nagel has locked in another confident against the spread pick for 49ers vs. Seahawks. We can tell you he's leaning Over the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins 49ers vs. Seahawks on Thanksgiving? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the 49ers vs. Seahawks spread to jump on, all from the expert who's an outstanding 24-10 on picks involving the Seahawks!