Backing non-conference road favorites can be dicey, but this Cardinals team looks too good to pass up at this number. The Bills’ struggles have been well documented, and although I think the defense is better than they’ve shown thus far, stopping Arizona’s offense may be too tall a task. The offense will again be without top lineman Cordy Glenn, and it’s looking like Sammy Watkins will miss the game as well, making the Bills much easier to defend. The Cardinals are top five on offense and defense in net yards per pass attempt, and they’ll prove why in Buffalo.