Xavier vs. Ohio State odds, line, spread: Proven model reveals college basketball picks, predictions for Nov. 18, 2021

The Xavier Musketeers will take on the No. 19 Ohio State Buckeyes at 6:30 p.m. ET Thursday at Cintas Center. The Musketeers are 2-0 while OSU is 3-0. OSU ended last year fifth in the Big Ten, while Xavier ended up seventh in the Big East. 

The Buckeyes are favored by 2.5 points in the latest Xavier vs. Ohio State odds from Caesars Sportsbook, and the over-under is set at 139.5. Before you make any Ohio State vs. Xavier picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Xavier vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Xavier vs. Ohio State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!