Xavier vs. Duke odds, line, spread: Proven model reveals college basketball picks, predictions for Nov. 25, 2022

The Xavier Musketeers will take on the No. 8 Duke Blue Devils at 3:30 p.m. ET on Friday at the Moda Center at the Rose Quarter. Duke advanced to the semifinals of the Phil Knight Legacy Tournament with a win at Oregon State, while Xavier got past Florida in a 90-83 final. The Blue Devils are favored by 4.5 points in the latest Xavier vs. Duke odds from Caesars Sportsbook, and the over/under is set at 147. 

Before you make any Duke vs. Xavier picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,400 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, it has simulated Duke vs. Xavier 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Xavier vs. Duke? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!