Syracuse vs. Louisville odds, line, spread: Proven model reveals college football picks, predictions for Week 1, 2022

An ACC battle is on tap between the Syracuse Orange and the Louisville Cardinals at 8 p.m. ET on Saturday at Carrier Dome. Louisville ended last year fourth in the Atlantic Division with an overall record of 6-7, while Syracuse finished sixth 5-7. 

The Cardinals are favored by 4.5 points in the latest Syracuse vs. Louisville odds from Caesars Sportsbook, and the over-under is set at 56.5. Before you make any Louisville vs. Syracuse picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Syracuse vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Syracuse vs. Louisville? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!