South Florida vs. BYU odds, line, spread: Proven model reveals college football picks, predictions for Week 1, 2022

The South Florida Bulls will take on the No. 25 BYU Cougars at 4 p.m. ET on Saturday at Raymond James Stadium. BYU picked up a 35-27 win over South Florida when the teams met last season. The Cougars are favored by 11.5 points in the latest South Florida vs. BYU odds from Caesars Sportsbook, while the over/under is set at 58. 

Before you make any BYU vs. South Florida picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated South Florida vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 70% of simulations. You absolutely need to see it before locking in your own picks.

So who wins South Florida vs. BYU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!