San Francisco vs. Loyola Chicago odds, line, spread: Proven model reveals college basketball picks, predictions for Jan. 6, 2022

The San Francisco Dons will take on the Loyola Chicago Ramblers at 2 p.m. ET on Thursday at Bruin Arena. Loyola Chicago is 9-2 and San Francisco is 13-1. This matchup was put together at the last minute due to COVID-19 postponements and will be played in Salt Lake City. 

The Ramblers are favored by 2.5 points in the latest San Francisco vs. Loyola Chicago odds from Caesars Sportsbook, while the over-under is set at 130. Before you make any Loyola Chicago vs. San Francisco picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated San Francisco vs. Loyola Chicago 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins San Francisco vs. Loyola Chicago? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.