Panthers vs. Saints odds, line, spread: Proven model reveals NFL picks, predictions for Week 3, 2022

A Week 3 NFC South battle is on tap between Baker Mayfield, Christian McCaffrey, and the Carolina Panthers and Jameis Winston, Michael Thomas, and the New Orleans Saints at 1 p.m. ET on Sunday at Bank of America Stadium. Carolina is 0-2 while New Orleans is 1-1. The Saints are coming off a 20-10 loss to the Tampa Bay Buccaneers, while the Panthers are looking to rebound from a 19-16 loss to the New York Giants.

New Orleans is favored by 2.5 points in the latest Panthers vs. Saints odds from Caesars Sportsbook, and the over/under is set at 41. Before you make any Saints vs. Panthers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Panthers vs. Saints 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits more than 50% of the time. You absolutely need to see it before locking in your own picks.

So who wins Panthers vs. Saints? And which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.