Michigan State vs. Penn State odds, line, spread: Proven model reveals college football picks, predictions for Week 13, 2021

A Big Ten battle is on tap between the Michigan State Spartans and the Penn State Nittany Lions at 3:30 p.m. ET on Saturday at Spartan Stadium. MSU is 9-2 overall and 5-0 at home, while Penn State is 7-4 overall and 2-2 on the road. The latest Michigan State vs. Penn State odds from Caesars Sportsbook list the Nittany Lions as the 1.5-point favorite and the over-under is set at 52. Before you make any Penn State vs. Michigan State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Michigan State vs. Penn State 10,000 times and the results are in. We can tell you that the model is leaning under and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Michigan State vs. Penn State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!