LSU vs. Mississippi State odds, line, spread: Proven model reveals college football picks, predictions for Week 3, 2022

An SEC battle is on tap between the LSU Tigers and the Mississippi State Bulldogs at 6 p.m. ET on Saturday at Tiger Stadium. LSU is 1-1 while MSU is 2-0. The Bulldogs ended last year third in the West Division, while LSU ended up sixth. 

The Bulldogs are favored by 2.5 points in the latest LSU vs. Mississippi State odds from Caesars Sportsbook, and the over/under is set at 53.5. Before you make any Mississippi State vs. LSU picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated LSU vs. Mississippi State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins LSU vs. Mississippi State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!