Loyola Chicago vs. Illinois odds, lines: Proven model reveals college basketball picks for the 2021 NCAA Tournament second round matchup

The top-seeded Illinois Fighting Illini will meet the eighth-seeded Loyola Chicago Ramblers in an NCAA Tournament Midwest Region second-round matchup Sunday. Tip-off from Bankers Life in Indianapolis is set for 12:10 p.m. ET. William Hill Sportsbook lists Illinois as a 7.5-point favorite, while the Over-Under for total points scored is 133.5 in the latest Loyola Chicago vs. Illinois odds (see up-to-date lines for every game on our college basketball odds page). 

Before making any Loyola Chicago vs. Illinois picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,500 for $100 players on its top-rated college basketball picks against the spread. It has also returned almost $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Loyola Chicago vs. Illinois. We can tell you the model is leaning Over the total, and it also says one side of the spread hits well over 60 percent of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Loyola Chicago vs. Illinois? And which side of the spread hits well over 60 percent of the time? ... Join SportsLine right now to find out which side of the Loyola Chicago vs. Illinois spread you should be all over Sunday, all from the model on a roll on college basketball picks!