Giants vs. Broncos odds, line, spread: Proven model reveals NFL picks, predictions for Week 1, 2021

The New York Giants will take on the Denver Broncos at 4:25 p.m. ET on Sunday at MetLife Stadium. The Giants started out 0-5 last season and finished at 6-10. The Broncos finished 5-11, losing five of their last six games. 

Denver is favored by three points in the latest Giants vs. Broncos odds from Caesars Sportsbook, and the over-under is set at 41.5. Before you make any Broncos vs. Giants picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated Giants vs. Broncos 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.    

So who wins Giants vs. Broncos? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!