Georgetown vs. DePaul odds, line, spread: Proven model reveals college basketball picks, predictions for Feb. 24, 2022

A Big East battle is on tap between the Georgetown Hoyas and the DePaul Blue Demons at 8 p.m. ET on Thursday at Capital One Arena on CBS Sports Network. Georgetown is 6-20 overall and 6-9 at home, while DePaul is 12-14 overall and 3-7 on the road. The Blue Demons are ranked 10th in the Big East; Georgetown is ranked 11th. 

The Blue Demons are favored by 2.5 points in the latest Georgetown vs. DePaul odds from Caesars Sportsbook, while the over-under is set at 146. Before you make any DePaul vs. Georgetown picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Georgetown vs. DePaul 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Georgetown vs. DePaul? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.